Kuhen, K. L. : rechercher sur Z-Library

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1

Design, synthesis, and biological evaluations of novel quinolones as HIV-1 non-nucleoside reverse transcriptase inhibitors

David Ellis, Kelli L. Kuhen, Beth Anaclerio, Baogen Wu, Karen Wolff, Hong Yin, Badry Bursulaya, Jeremy Caldwell, Donald Karanewsky, Yun He

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2006

Langue:

english

Fichier:

PDF, 153 KB

english, 2006

2

Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery

Meister, S., Plouffe, D. M., Kuhen, K. L., Bonamy, G. M. C., Wu, T., Barnes, S. W., Bopp, S. E., Borboa, R., Bright, A. T., Che, J., Cohen, S., Dharia, N. V., Gagaring, K., Gettayacamin, M., Gordon, P

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 1.01 MB

english, 2011

3

Lentivirus Replication and Regulation

Tang, Hengli, Kuhen, Kelli L, Wong-Staal, Flossie

Journal:

Annual Review of Genetics

Année:

1999

Langue:

english

Fichier:

PDF, 472 KB

english, 1999

4

Direct inhibitors of InhA are active against Mycobacterium tuberculosis

Manjunatha, U. H., S. Rao, S. P., Kondreddi, R. R., Noble, C. G., Camacho, L. R., Tan, B. H., Ng, S. H., Ng, P. S., Ma, N. L., Lakshminarayana, S. B., Herve, M., Barnes, S. W., Yu, W., Kuhen, K., Blas

Journal:

Science Translational Medicine

Année:

2015

Langue:

english

Fichier:

PDF, 1.60 MB

english, 2015

5

Generation of dendritic cells from lentiviral vector-transduced CD34+ cells from HIV+ donors

A. Gruber, I. Chen, K.L. Kuhen, J.C. Wheat, P. Law, F. Wong-Staal

Journal:

Journal of Medical Virology

Année:

2003

Langue:

english

Fichier:

PDF, 108 KB

english, 2003

6

Synthesis and evaluation of N-aryl pyrrolidinones as novel anti-HIV-1 agents. Part 1

Baogen Wu, Kelli Kuhen, Truc Ngoc Nguyen, David Ellis, Beth Anaclerio, Xiaohui He, Kunyong Yang, Donald Karanewsky, Hong Yin, Karen Wolff, Kimberly Bieza, Jeremy Caldwell, Yun He

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2006

Langue:

english

Fichier:

PDF, 120 KB

english, 2006

7

Synthesis and biological evaluations of sulfanyltriazoles as novel HIV-1 non-nucleoside reverse transcriptase inhibitors

Zhiwei Wang, Baogen Wu, Kelli L. Kuhen, Badry Bursulaya, Truc N. Nguyen, Deborah G. Nguyen, Yun He

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2006

Langue:

english

Fichier:

PDF, 193 KB

english, 2006

8

4-Aminopyrimidines as novel HIV-1 inhibitors

Venkat R. Gadhachanda, Baogen Wu, Zhiwei Wang, Kelli L. Kuhen, Jeremy Caldwell, Helmut Zondler, Harald Walter, Mark Havenhand, Yun He

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2007

Langue:

english

Fichier:

PDF, 209 KB

english, 2007

9

Cell-based optimization of novel benzamides as potential antimalarial leads

Tao Wu, Advait Nagle, Tomoyo Sakata, Kerstin Henson, Rachel Borboa, Zhong Chen, Kelli Kuhen, David Plouffe, Elizabeth Winzeler, Francisco Adrian, Tove Tuntland, Jonathan Chang, Susan Simerson, Steven

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2009

Langue:

english

Fichier:

PDF, 478 KB

english, 2009

10

Discovery of novel 1H-imidazol-2-yl-pyrimidine-4,6-diamines as potential antimalarials

Xianming Deng, Advait Nagle, Tao Wu, Tomoyo Sakata, Kerstin Henson, Zhong Chen, Kelli Kuhen, David Plouffe, Elizabeth Winzeler, Francisco Adrian, Tove Tuntland, Jonathan Chang, Susan Simerson, Steven

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 2.44 MB

english, 2010

11

Design, synthesis and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part I

Tao Jiang, Kelli L. Kuhen, Karen Wolff, Hong Yin, Kimberly Bieza, Jeremy Caldwell, Badry Bursulaya, Tom Yao-Hsing Wu, Yun He

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2006

Langue:

english

Fichier:

PDF, 149 KB

english, 2006

12

Design, synthesis, and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part 2

Tao Jiang, Kelli L. Kuhen, Karen Wolff, Hong Yin, Kimberly Bieza, Jeremy Caldwell, Badry Bursulaya, Tove Tuntland, Kanyin Zhang, Donald Karanewsky, Yun He

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2006

Langue:

english

Fichier:

PDF, 156 KB

english, 2006

13

Imidazolopiperazines: Hit to Lead Optimization of New Antimalarial Agents

Wu, Tao, Nagle, Advait, Kuhen, Kelli, Gagaring, Kerstin, Borboa, Rachel, Francek, Caroline, Chen, Zhong, Plouffe, David, Goh, Anne, Lakshminarayana, Suresh B.

Journal:

Journal of Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 1.35 MB

english, 2011

14

Imidazolopiperazines: Lead Optimization of the Second-Generation Antimalarial Agents

Nagle, Advait, Wu, Tao, Kuhen, Kelli, Gagaring, Kerstin, Borboa, Rachel, Francek, Caroline, Chen, Zhong, Plouffe, David, Lin, Xuena, Caldwell, Christopher

Journal:

Journal of Medicinal Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 1.76 MB

english, 2012

15

Isolation of the Interferon-Inducible RNA-Dependent Protein KinasePkrPromoter and Identification of a Novel DNA Element within the 5′-Flanking Region of Human and MousePkrGenes

KELLI L. KUHEN, CHARLES E. SAMUEL

Journal:

Année:

1997

Langue:

english

Fichier:

PDF, 216 KB

english, 1997

16

Mechanism of Interferon Action: Functional Characterization of Positive and Negative Regulatory Domains That Modulate Transcriptional Activation of the Human RNA-Dependent Protein KinasePkrPromoter

Kelli L. Kuhen, Charles E. Samuel

Journal:

Année:

1999

Langue:

english

Fichier:

PDF, 298 KB

english, 1999

17

Alternative Splice Variants of the Human PKR Protein Kinase Possessing Different 5′-Untranslated Regions: Expression in Untreated and Interferon-Treated Cells and Translational Activity

Ken Kawakubo, Kelli L. Kuhen, Jill W. Vessey, Cyril X. George, Charles E. Samuel

Journal:

Année:

1999

Langue:

english

Fichier:

PDF, 239 KB

english, 1999

18

Phospholipids regulate growth and function of MDCK cells in hormonally defined serum free medium

Nabil Bashir, Kelli Kuhen, Mary Taub

Journal:

In Vitro Cellular & Developmental Biology - Animal

Année:

1992

Langue:

english

Fichier:

PDF, 617 KB

english, 1992

19

Propofol infusion technique for outpatient general anesthesia

Lionel M Candelaria, R.Kuhen Smith

Journal:

Journal of Oral and Maxillofacial Surgery

Année:

1995

Langue:

english

Fichier:

PDF, 537 KB

english, 1995

20

Identification of novel therapeutic targets for HIV infection through functional genomic cDNA screening

Deborah G. Nguyen, Hong Yin, Yingyao Zhou, Karen C. Wolff, Kelli L. Kuhen, Jeremy S. Caldwell

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 527 KB

english, 2007

21

Structural Organization of the Human Gene (PKR) Encoding an Interferon-Inducible RNA-Dependent Protein Kinase (PKR) and Differences from Its Mouse Homolog

Kelli L. Kuhen, Xueyu Shen, Elliot R. Carlisle, Ami L. Richardson, Heinz-Ulrich G. Weier, Hideo Tanaka, Charles E. Samuel

Journal:

Année:

1996

Langue:

english

Fichier:

PDF, 127 KB

english, 1996

22

Mechanism of interferon action Sequence of the human interferon-inducible RNA-dependent protein kinase (PKR) deduced from genomic clones

Kelli L. Kuhen, Xueyu Shen, Charles E. Samuel

Journal:

Année:

1996

Langue:

english

Fichier:

PDF, 275 KB

english, 1996

23

In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen

Plouffe, David, Brinker, Achim, McNamara, Case, Henson, Kerstin, Kato, Nobutaka, Kuhen, Kelli, Nagle, Advait, Adrián, Francisco, Matzen, Jason T., Anderson, Paul, Nam, Tae-gyu, Gray, Nathanael S., Cha

Journal:

Proceedings of the National Academy of Sciences

Année:

2008

Langue:

english

Fichier:

PDF, 47 KB

english, 2008

24

Design, Synthesis, and Biological Evaluation of Indole-2-carboxamides: A Promising Class of Antituberculosis Agents

Kondreddi, Ravinder Reddy, Jiricek, Jan, Rao, Srinivasa P. S., Lakshminarayana, Suresh B., Camacho, Luis R., Rao, Ranga, Herve, Maxime, Bifani, Pablo, Ma, Ngai Ling, Kuhen, Kelli, Goh, Anne, Chatterje

Journal:

Journal of Medicinal Chemistry

Année:

2013

Langue:

english

Fichier:

PDF, 692 KB

english, 2013

25

Mutations in the P-Type Cation-Transporter ATPase 4, PfATP4, Mediate Resistance to Both Aminopyrazole and Spiroindolone Antimalarials

Flannery, Erika L., McNamara, Case W., Kim, Sang Wan, Kato, Tomoyo Sakata, Li, Fengwu, Teng, Christine H., Gagaring, Kerstin, Manary, Micah J., Barboa, Rachel, Meister, Stephan, Kuhen, Kelli, Vinetz,

Journal:

ACS Chemical Biology

Année:

2015

Langue:

english

Fichier:

PDF, 2.22 MB

english, 2015

26

Whole-genome sequencing and microarray analysis of ex vivo Plasmodium vivax reveal selective pressure on putative drug resistance genes

Neekesh V. Dharia, A. Taylor Bright, Scott J. Westenberger, S. Whitney Barnes, Serge Batalov, Kelli Kuhen, Rachel Borboa, Glenn C. Federe, Colleen M. McClean, Joseph M. Vinetz, Victor Neyra, Alejandro

Journal:

Proceedings of the National Academy of Sciences

Année:

2010

Langue:

english

Fichier:

PDF, 1.34 MB

english, 2010

27

Identification of broad-spectrum antiviral compounds and assessment of the druggability of their target for efficacy against respiratory syncytial virus (RSV)

Bonavia, A., Franti, M., Pusateri Keaney, E., Kuhen, K., Seepersaud, M., Radetich, B., Shao, J., Honda, A., Dewhurst, J., Balabanis, K., Monroe, J., Wolff, K., Osborne, C., Lanieri, L., Hoffmaster, K.

Journal:

Proceedings of the National Academy of Sciences

Année:

2011

Langue:

english

Fichier:

PDF, 1.49 MB

english, 2011

28

Whole-genome sequencing and microarray analysis of ex vivo Plasmodium vivax reveal selective pressure on putative drug resistance genes

Dharia, N. V., Bright, A. T., Westenberger, S. J., Barnes, S. W., Batalov, S., Kuhen, K., Borboa, R., Federe, G. C., McClean, C. M., Vinetz, J. M., Neyra, V., Llanos-Cuentas, A., Barnwell, J. W., Walk

Journal:

Proceedings of the National Academy of Sciences

Année:

2010

Langue:

english

Fichier:

PDF, 608 KB

english, 2010

29

"UnPAKing" Human Immunodeficiency Virus (HIV) Replication: Using Small Interfering RNA Screening To Identify Novel Cofactors and Elucidate the Role of Group I PAKs in HIV Infection

Nguyen, D. G., Wolff, K. C., Yin, H., Caldwell, J. S., Kuhen, K. L.

Journal:

Journal of Virology

Année:

2006

Langue:

english

Fichier:

PDF, 392 KB

english, 2006

30

Identification of Cellular Cofactors for Human Immunodeficiency Virus Replication via a Ribozyme-Based Genomics Approach

Waninger, S., Kuhen, K., Hu, X., Chatterton, J. E., Wong-Staal, F., Tang, H.

Journal:

Journal of Virology

Année:

2004

Langue:

english

Fichier:

PDF, 484 KB

english, 2004

31

Just-in-Time Purification: An Effective Solution for Cherry-Picking and Purifying Active Compounds from Large Legacy Libraries

Guintu, C., Kwok, M., Hanlon, J. J., Spalding, T. A., Wolff, K., Yin, H., Kuhen, K., Sasher, K., Calvin, P., Jiang, S., Zhou, Y., Isbell, J. J.

Journal:

Journal of Biomolecular Screening

Année:

2006

Langue:

english

Fichier:

PDF, 155 KB

english, 2006

32

A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy

Pethe, Kevin, Sequeira, Patricia C., Agarwalla, Sanjay, Rhee, Kyu, Kuhen, Kelli, Phong, Wai Yee, Patel, Viral, Beer, David, Walker, John R., Duraiswamy, Jeyaraj, Jiricek, Jan, Keller, Thomas H., Chatt

Journal:

Nature Communications

Année:

2010

Langue:

english

Fichier:

PDF, 538 KB

english, 2010

33

The emerging threat of artemisinin resistance in malaria: focus on artemether-lumefantrine

Djimde, Abdoulaye A, Makanga, Michael, Kuhen, Kelli, Hamed, Kamal

Journal:

Expert Review of Anti-infective Therapy

Année:

2015

Langue:

english

Fichier:

PDF, 440 KB

english, 2015

34

No Robust Evidence of Lumefantrine Resistance

Hamed, Kamal, Kuhen, Kelli

Journal:

Antimicrobial Agents and Chemotherapy

Année:

2015

Langue:

english

Fichier:

PDF, 125 KB

english, 2015

35

KAF156 Is an Antimalarial Clinical Candidate with Potential for Use in Prophylaxis, Treatment, and Prevention of Disease Transmission

Kuhen, K. L., Chatterjee, A. K., Rottmann, M., Gagaring, K., Borboa, R., Buenviaje, J., Chen, Z., Francek, C., Wu, T., Nagle, A., Barnes, S. W., Plouffe, D., Lee, M. C. S., Fidock, D. A., Graumans, W.

Journal:

Antimicrobial Agents and Chemotherapy

Année:

2014

Langue:

english

Fichier:

PDF, 645 KB

english, 2014

36

Phospholipids Regulate Growth and Function of MDCK Cells in Hormonally Defined Serum Free Medium

Nabil Bashir, Kelli Kuhen and Mary Taub

Journal:

In Vitro Cellular & Developmental Biology

Année:

1992

Langue:

english

Fichier:

PDF, 405 KB

english, 1992

37

Systematic Identification and Management of Sleep Apnea (SA) in Hospitalized Patients: Implementation of an Interprofessional Care Guideline in a Community Hospital

Kuhen, Lisa, Woidtke, Robyn, Wynd, Christine, Baker, Janet

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 17 KB

english, 2014

38

NIH Public Access

Meister, Stephan, Plouffe, David M, Kuhen, Kelli L, Bonamy, Ghislain M C, Wu, Tao, Barnes, Whitney, Bopp, Selina E, Borboa, Rachel, Bright, A Taylor, Che, Jianwei, Dharia, Neekesh V, Gagaring, Kerstin

Année:

2012

Langue:

english

Fichier:

PDF, 1.72 MB

english, 2012

39

Differential Effects of HIV-1 Protease Inhibitors on Dendritic Cell Immunophenotype and Function

Gruber, Andreas, Wheat, Jeffery C., Kuhen, Kelli L., Looney, David J., Wong-Staal, Flossie

Journal:

Journal of Biological Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 108 KB

english, 2001

40

The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis

Janes, Jeff, Young, Megan E., Chen, Emily, Rogers, Nicole H., Burgstaller-Muehlbacher, Sebastian, Hughes, Laura D., Love, Melissa S., Hull, Mitchell V., Kuhen, Kelli L., Woods, Ashley K., Joseph, Sean

Journal:

Proceedings of the National Academy of Sciences

Année:

2018

Langue:

english

Fichier:

PDF, 721 KB

english, 2018

41

Operation Enduring Freedom: Trends in Combat Casualty Care by Forward Surgical Teams Deployed to Afghanistan

Shen-Gunther, Jane, Ellison, Richard, Kuhens, Charles, Roach, Christopher J., Jarrard, Steve

Journal:

Military Medicine

Année:

2011

Langue:

english

Fichier:

PDF, 1.10 MB

english, 2011

42

Dendritic cells transduced by multiply deleted HIV-1 vectors exhibit normal phenotypes and functions and elicit an HIV-specific cytotoxic T-lymphocyte response in vitro

Gruber, Andreas, Kan-Mitchell, June, Kuhen, Kelli L., Mukai, Tetsu, Wong-Staal, Flossie

Journal:

Année:

2000

Fichier:

PDF, 204 KB

2000

43

O CUIDADO Ã PESSOA COM DIABETES MELLITUS E SUA FAMÃLIA

Dornelles, Soraia Schoeller, Silva, Denise Maria Guerreiro Vieira da, Mattosinho, Mariza Maria Serafim, Kuhen, Adriana Eich, BaiÃ£o, Soraya, Sandoval, Rita

Journal:

Cogitare Enfermagem

Année:

2013

Fichier:

PDF, 227 KB

2013